Canadian Association of Radiologists Journal
Volume 62, Issue 3 , Pages 183-189 , August 2011

Reproducibility of Peripheral Quantitative Computed Tomography Measurements at the Radius and Tibia in Healthy Pre- and Postmenopausal Women

  • Kristina A. Szabo, MSc, PhD

      Affiliations

    • Department of Nuclear Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    • Department of Radiology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
    • Corresponding Author InformationAddress for correspondence: Kristina A. Szabo, MSc, PhD, c/o Colin E. Webber, PhD, Department of Nuclear Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8N 3Z5, Canada.
  • ,
  • Colin E. Webber, PhD

      Affiliations

    • Department of Nuclear Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    • Department of Radiology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
  • ,
  • Christopher Gordon, PhD

      Affiliations

    • Department of Nuclear Medicine, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada
    • Department of Radiology, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
  • ,
  • Jonathan D. Adachi, MD

      Affiliations

    • Department of Medicine, McMaster University, Hamilton, Ontario, Canada
  • ,
  • Richard Tozer, MD, PhD

      Affiliations

    • Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
  • ,
  • Alexandra Papaioannou, MD, MSc

      Affiliations

    • Department of Medicine, McMaster University, Hamilton, Ontario, Canada

References 

  1. Felsenberg D, Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther. 2005;27:1–11
  2. Ruegsegger P, Elsasser U, Anliker M, et al. Quantification of bone mineralization using computed tomography. Radiology. 1976;121:93–97
  3. Sievanen H, Koskue V, Rauhio A, et al. Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision. J Bone Miner Res. 1998;13:871–882
  4. Braun MJ, Meta MD, Schneider P, et al. Clinical evaluation of a high-resolution new peripheral quantitative computerized tomography (pQCT) scanner for the bone densitometry at the lower limbs. Phys Med Biol. 1998;43:2279–2294
  5. Binkley TL, Specker BL. pQCT measurement of bone parameters in young children: validation of technique. J Clin Densitom. 2000;3:9–14
  6. Findlay SC, Eastell R, Ingle BM. Measurement of bone adjacent to tibial shaft fracture. Osteoporos Int. 2002;13:980–989
  7. Gluer CC, Blake G, Lu Y, et al. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int. 1995;5:262–270
  8. Hangartner TN, Gilsanz V. Evaluation of cortical bone by computed tomography. J Bone Miner Res. 1996;11:1518–1525
  9. Augat P, Gordon CL, Lang TF, et al. Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT). Phys Med Biol. 1998;43:2873–2883
  10. Prevrhal S, Engelke K, Kalender WA. Accuracy limits for the determination of cortical width and density: the influence of object size and CT imaging parameters. Phys Med Biol. 1999;44:751–764
  11. Butz S, Wuster C, Scheidt-Nave C, et al. Forearm BMD as measured by peripheral quantitative computed tomography (pQCT) in a German reference population. Osteoporos Int. 1994;4:179–184
  12. Grampp S, Lang P, Jergas M, et al. Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: short-term precision in vivo and comparison to dual X-ray absorptiometry. J Bone Miner Res. 1995;10:1566–1576
  13. Takada M, Engelke K, Hagiwara S, et al. Accuracy and precision study in vitro for peripheral quantitative computed tomography. Osteoporos Int. 1996;6:207–212
  14. Augat P, Fuerst T, Genant HK. Quantitative bone mineral assessment at the forearm: a review. Osteoporos Int. 1998;8:299–310
  15. Martin JC, Campbell MK, Reid DM. A comparison of radial peripheral quantitative computed tomography, calcaneal ultrasound, and axial dual energy X-ray absorptiometry measurements in women aged 45-55 yr. J Clin Densitom. 1999;2:265–273
  16. Guglielmi G, De Serio A, Fusilli S, et al. Age-related changes assessed by peripheral QCT in healthy Italian women. Eur Radiol. 2000;10:609–614
  17. Boonen S, Cheng X, Nicholson PH, et al. The accuracy of peripheral skeletal assessment at the radius in estimating femoral bone density as measured by dual-energy X-ray absorptiometry: a comparative study of single-photon absorptiometry and computed tomography. J Intern Med. 1997;242:323–328
  18. MacNeil JA, Boyd SK. Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2008;30:792–799
  19. Boutroy S, Bouxsein ML, Munoz F, et al. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005;90:6508–6515
  20. Tsurusaki K, Ito M, Hayashi K. Differential effects of menopause and metabolic disease on trabecular and cortical bone assessed by peripheral quantitative computed tomography (pQCT). Br J Radiol. 2000;73:14–22
  21. Groll O, Lochmüller EM, Bachmeier M, et al. Precision and intersite correlation of bone densitometry at the radius, tibia and femur with peripheral quantitative CT. Skeletal Radiol. 1999;28:696–702

PII: S0846-5371(10)00113-0

doi: 10.1016/j.carj.2010.04.011

Canadian Association of Radiologists Journal
Volume 62, Issue 3 , Pages 183-189 , August 2011